McMaster University researchers are making major inroads in the battle against so-called superbugs and laying the groundwork for highly effective antibiotics of the future, a scientific journal says.
An article in the current issue of Nature Biotechnology outlines a new approach to isolating naturally-occurring antibiotics in soil bacteria that could produce new drugs that are effective on antibiotic-resistant bacteria.
It’s well known bacteria in soils and soil fungi produce antibiotics. But the problem has been going through millions of strains to find ones that are effective against new superbugs and worth pursuing commercially. Most antibiotics were discovered in the 1940s and ’50s when bacteria and fungi that grow in nature were screened. Penicillin was discovered this way.
“It’s like trying to find a needle in a haystack,” says Gerry Wright, professor and scientific director of the Michael G. DeGroote Institute for Infectious Disease Research.
The new process essentially involves applying commercially available antibiotics to soil samples in Petri dishes. That kills off most of the bacteria, and the researchers focus their attention on the naturally-occurring antibiotics associated with the bacteria that remains. This enables researchers to screen for new drugs 10,000 times more effectively.
“It’s like back to the future. Soil bacteria and soil fungi are where we found them to begin with and we drifted away from that source,” said Wright.
The Latest on: Superbug research
- World Animal Protection research finds superbugs in pork products from Carrefour in Spain and Walmart in Brazil on December 24, 2018 at 7:50 pm
NEW YORK: Bacteria resistant to antibiotics most critically important to humans has been found in pork from supermarket shelves in Brazil, Spain and Thailand. This is a symptom of the routine overuse ... […]
- Christmas prawn shells helping to fight antibiotic-resistant super bugs, trial shows on December 23, 2018 at 3:15 pm
Trials have shown the anti-bacterial membrane, made from an active ingredient called chitosan, could fight off "golden staph", a deadly super bug that has wreaked havoc in hospitals. Lead researcher D... […]
- Merrikh Lab working to defeat drug-resistant superbugs on December 20, 2018 at 11:56 am
A new Vanderbilt University biochemistry professor is working to defeat drug-resistant superbugs by blocking ... She and her husband, Chris Merrikh, a research assistant professor in biochemistry ... […]
- 10 ways remarkable research is protecting health on December 20, 2018 at 8:51 am
The research team has discovered the process by which cells move ... Some of the most inspiring actions to stop the rise and spread of superbugs are happening in lower and middle-income countries, whe... […]
- Researcher nets top 10 innovator award for fighting superbugs on December 17, 2018 at 10:31 pm
“‘Superbugs’, such as Golden Staph ... Dr Richter has expanded her ground-breaking research by teaming up with researchers, clinicians and industry partners around the globe. […]
via Google News and Bing News