Georgetown University Medical Center (GUMC) researchers say a compound derived from cruciferous vegetable such as cabbage, cauliflower and broccoli protected rats and mice from lethal doses of radiation.
Their study, published today in the Proceedings of the National Academy of Sciences (PNAS) suggests the compound, already shown to be safe for humans, may protect normal tissues during radiation therapy for cancer treatment and prevent or mitigate sickness caused by radiation exposure.
The compound, known as DIM (3,3’-diindolylmethane), previously has been found to have cancer preventive properties.
“DIM has been studied as a cancer prevention agent for years, but this is the first indication that DIM can also act as a radiation protector,” says the study’s corresponding author, Eliot Rosen, MD, PhD, of Georgetown Lombardi Comprehensive Cancer Center, a part of GUMC.
For the study, the researchers irradiated rats with lethal doses of gamma ray radiation. The animals were then treated with a daily injection of DIM for two weeks, starting 10 minutes after the radiation exposure.
The result was stunning, says Rosen, a professor of oncology, biochemistry and cell & molecular biology, and radiation medicine. “All of the untreated rats died, but well over half of the DIM-treated animals remained alive 30 days after the radiation exposure.”
Rosen adds that DIM also provided protection whether the first injection was administered 24 hours before or up to 24 hours after radiation exposure.
“We also showed that DIM protects the survival of lethally irradiated mice,” Rosen says. In addition, irradiated mice treated with DIM had less reduction in red blood cells, white blood cells and platelets — side effects often seen in patients undergoing radiation treatment for cancer.
Rosen says this study points to two potential uses of the compound. “DIM could protect normal tissues in patients receiving radiation therapy for cancer, but could also protect individuals from the lethal consequences of a nuclear disaster.”
The Latest on: Radiation protector
Radiation Monitoring and Safety Market 2025 Industry Production, Supply, Sales and Demand Market Research Report
on August 12, 2018 at 11:35 pm
Radiation monitoring is a technique used in determining radiation dose or any radionuclide contamination for monitoring the exposure to radiation or radioactive substances. Environmental protection ag... […]
Wearable ‘microbrewery’ saves human body from radiation damage
on August 10, 2018 at 7:52 am
Numbers from the readout system translate to rads – the units used by entities like the Occupational Safety and Health Administration to specify limits on how much radiation human tissue can safely ab... […]
Social News 10/8
on August 9, 2018 at 6:41 pm
Vietnam’s Department of Radiation and Nuclear Safety under the Ministry of Science and Technology, the US’s Department of Energy in collaboration with Da Nang city’s Department of Science and Technolo... […]
Radiation Protection Glasses Market SWOT Analysis of Leading Key Players AADCO Medica, Aktif X-ray, BIODEX
on August 6, 2018 at 6:11 am
HTF MI recently introduced Global Radiation Protection Glasses Market study with in-depth overview, describing about the Product / Industry Scope and elaborates market outlook and status to 2023. The ... […]
Tri-City conference to focus on radiation exposure safety
on August 3, 2018 at 3:41 pm
This is a question many Tri-Citians have been asked when we visit the west side of the state. While it’s usually meant as joke, it reveals a lack of knowledge of radiation and its effects. How much do ... […]
via Google News and Bing News