“In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease”
In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a “robust” treatment for crippling stroke.
“In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease,” says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute.
It focused on exosomes, blister-like microscopic “bubbles” that once were thought to carry and get rid of “old” proteins that were no longer needed by the body. After they were recently found to also carry RNA, whole new fields of study were suggested – including the pioneering work at Henry Ford.
The research team found that after inducing stroke in lab rats, injecting exosomes containing this genetic material into their blood prompted remodeling of the affected brain, including increased production of new brain cells, blood vessels and neural rewiring. Together, these effects significantly improved neurological function that had been impaired by stroke.
Using bone marrow from the adult rats, the researchers extracted stem cells – specifically mesenchymal cells, or MSCs – that were then employed to generate exosomes.
The researchers induced stroke by occluding an artery in the brain of each rat to block blood flow for two hours. Twenty-four hours later, they injected the exosomes into a vein in each rat’s tail.
The rats’ physical agility and neurological responses were tested before stroke and after treatment with the exosomes, and the results were compared.
“All rats showed severe functional loss one day after treatment, but gradual and eventually significant improvement during the four-week period that followed,” Dr. Chopp says. “This discovery provides a novel treatment for stroke, and possibly other neurological diseases.”
The Latest on: Treatment for Stroke
Will a new payment model for treating opioid abuse help meet demand for treatment?
on April 20, 2018 at 12:23 pm
The treatment of patients with opioid addiction takes time ... congestive heart failure, HIV, Hepatitis and stroke, according to NIH's National Institute on Drug Abuse. "This might very well turn into a cost saver for the third-party payer because ... […]
NEW ‘BRAIN HEALTH INDEX’ CAN PREDICT HOW WELL PATIENTS WILL DO AFTER STROKE
on April 20, 2018 at 8:44 am
“Eventually we hope to introduce brain health index into clinical practice so that it may improve early identification and treatment of cognitive decline and dementia after stroke.” The paper, ‘The brain health index: Towards a combined measure of ... […]
Compound 21 improves stroke outcome by reducing lingering inflammation
on April 20, 2018 at 6:45 am
In the case of stroke, they suggest studies should include blinding results, so scientists don’t know which animals got which treatment, randomized enrollment of older animals and looking at the impact of tPA on whatever new therapy is being studies. […]
Experimental compound reduces destructive inflammation to improve stroke outcome
on April 20, 2018 at 4:05 am
In the case of stroke, they suggest studies should include blinding results, so scientists don't know which animals got which treatment, randomized enrollment of older animals and looking at the impact of tPA on whatever new therapy is being studies. […]
SPECIAL REPORT: Mechanical Thrombectomy is a game changer for stroke treatment
on April 19, 2018 at 10:40 pm
AUGUSTA, Ga. (WJBF) - "Stroke Belt" or "Stroke Alley" is a name given to a 9-state region in the southeastern United States that has been recognized by public health authorities for having an unusually high incidence of stroke: South Carolina and Georgia ... […]
GUEST VIEW: Revolution in stroke care right here in Utica
on April 18, 2018 at 11:56 pm
friends and neighbors – will experience a stroke or stroke-like symptoms. Nearly 800 of those individuals will receive treatment at the Mohawk Valley Health System (MVHS) sometime during the course of this life-altering event. Many of the individuals ... […]
Healthcast: Stroke recovery video game
on April 18, 2018 at 5:47 pm
“Patients go from using their arm five to ten percent of the time compared to their stroke before treatment to 50 percent of the time,” Uswatte told Ivanhoe. But CI therapy is expensive. With this at-home video game … “The costs are reduced because ... […]
Comparing strategies to guide blood pressure treatment
on April 18, 2018 at 5:05 am
A strategy that examines a patient's overall heart disease and stroke risk to determine blood pressure treatment—rather than blood pressure levels alone—is more effective at preventing events like heart attacks, strokes and death, according to a new ... […]
New method could transform aphasia treatment after stroke
on April 18, 2018 at 4:06 am
A new treatment has been shown to significantly improve the speech and word production of stroke patients. The treatment- developed by a speech therapist and cognitive neuroscientists at The University of Manchester- uses special software which gradually ... […]
Batavia officials introduced to faster treatment for stroke victims
on April 15, 2018 at 3:24 pm
[Critical care nurse Mehr Mohajer-Esfahani is shown with the CT scanner inside the mobile stroke unit from Northwestern Medicine Central DuPage Hospital. The ambulance is beginning to serve TriCities residents.] BATAVIA – For the victim of a stroke ... […]
via Google News and Bing News