Sep 202013

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Decompression surgery has a significant improvement in both the symptoms and quality of life of CSM patients at all levels of severity

In a world-first, decompression surgery has been shown to be  an effective procedure to treat cervical spondylotic myelopathy (CSM) – a common progressive, degenerative disease of the spine that can lead to paralysis – according to the results of a multi-centre clinical trial published today.

The study, with its use of multiple outcome measures to determine patient improvement, is the first research of its kind to show that decompression surgery has a significant improvement in both the symptoms and quality of life of CSM patients at all levels of severity.

The study, “Efficacy and Safety of Surgical Decompression in Patients with Cervical Spondylotic Myelopathy: Results of the AOSpine North America Prospective Multi-Center Study,” published in the Journal of Bone and Joint Surgery, found that patients with mild, moderate and severe CSM show significant recovery after undergoing decompression surgery – a procedure that alleviates pressure on the nerves of the spinal cord.

“The results of this trial support the use of decompression surgery as a viable treatment for Cervical Spondylotic Myelopathy and could lead to a change in practice to treat this condition,” said Dr. Michael Fehlings, neurosurgeon and Medical Director of the Krembil Neuroscience Centre, Toronto Western Hospital and the study’s lead author. “With few existing interventions available for these patients, it is encouraging to have data showing improvements in quality of life as a result of surgery, in some cases, even reversing serious neurological damage that could have resulted in paralysis.”

To date, the limited research and mixed reports have concluded that there was no added benefit from surgical intervention for CSM patients, and that the best approach was to monitor the progression of their condition and, in some cases, treat conservatively with non-surgical approaches. However, in 30 to 50 per cent of CSM cases, it has been observed that the condition gets progressively worse, impairing patients’ ability to walk and perform daily tasks such as dressing themselves and performing their own personal hygiene. This study clearly shows that many more patients with CSM could benefit from surgery than previously thought.

CSM is the leading cause of spinal cord dysfunction in the world, mostly affects people over the age of 50 and is very common in people of Asian and South Asian descent. Over time, the normal process of aging can sometimes lead to the narrowing of the spinal canal creating pressure on the spinal cord. As CSM progresses, it can cause neck stiffness, arm pain, numbness in the hands and, in severe cases, inhibits movement in limbs, impairs walking and can eventually lead to paralysis.

An unrecognized condition that is often misdiagnosed, CSM incidence and prevalence remain undetermined in Canada but, based on clinical caseloads and statistics from the U.S., is estimated to occur among 20 per cent of Canadians with approximately 10 per cent of them requiring surgery to treat the spinal cord dysfunction.

Other than medication to alleviate pain caused by the condition, there are no treatments available for CSM patients and surgery was usually only considered for the most severe cases in an attempt to stop further neurological deterioration.

From 2005 to 2007, researchers at 12 trial centres across North America, including Toronto Western Hospital, recruited patients with symptoms of CSM whose x-rays showed evidence of spinal cord compression. Patients were then categorized as having mild, moderate or severe CSM. The aim of the study was to evaluate the impact of decompression surgery on functional, quality of life and disability outcomes one year after patients had undergone surgery. The study also set out to determine, if the degree of improvement depended on the severity of CSM in patients before surgery.

Using a variety of outcome indices that measure the severity of functional and neurological impairment, such as the Nurick Grade and Neck Disability Index (NDI), researchers evaluated patients before and after surgery to determine the effect of the surgical intervention on the patients’ CSM.

At the one year follow up after decompression surgery, researchers found that the majority of study participants experienced statistically significant improvements in their condition. They also noted that for functional, disability and quality of life measures, the degree of improvement did not depend on the severity of preoperative symptoms, indicating that even cases of mild and moderate CSM benefit from surgical intervention.

Read more . . .


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