Rodent research suggests feasibility of restoring neuron function
Research from the School of Medicine at The University of Texas Health Science Center at San Antonio suggests the exciting possibility of using cell transplants to treat schizophrenia.
Cells called “interneurons” inhibit activity within brain regions, but this braking or governing function is impaired in schizophrenia. Consequently, a group of nerve cells called the dopamine system go into overdrive. Different branches of the dopamine system are involved in cognition, movement and emotions.
“Since these cells are not functioning properly, our idea is to replace them,” said study senior author Daniel Lodge, Ph.D., assistant professor of pharmacology in the School of Medicine.
Transplant restored normal function
Dr. Lodge and lead author Stephanie Perez, graduate student in his laboratory, biopsied tissue from rat fetuses, isolated cells from the tissue and injected the cells into a brain center called the hippocampus. This center regulates the dopamine system and plays a role in learning, memory and executive functions such as decision making. Rats treated with the transplanted cells have restored hippocampal and dopamine function.
Stem cells are able to become different types of cells, and in this case interneurons were selected. “We put in a lot of cells and not all survived, but a significant portion did and restored hippocampal and dopamine function back to normal,” Dr. Lodge said.
‘You can essentially fix the problem’
Unlike traditional approaches to treating schizophrenia, such as medications and deep-brain stimulation, transplantation of interneurons potentially can produce a permanent solution. “You can essentially fix the problem,” Dr. Lodge said. “Ultimately, if this is translated to humans, we want to reprogram a patient’s own cells and use them.”
The Latest on: Schizophrenia
Bergenfield police search for missing resident with schizophrenia
on April 19, 2018 at 11:57 am
BERGENFIELD — Police are asking for help in finding a 40-year-old resident who suffers from paranoid schizophrenia. Thomas Araneo, who resides in a group home in the borough, was reported missing by his group home supervisor on April 16 and is without ... […]
Police Looking For Missing Bergen Man With Schizophrenia
on April 19, 2018 at 10:31 am
BERGEN COUNTY, NJ — Bergenfield police are looking for a missing man suffering from paranoid Schizophrenia who went missing Monday. Thomas Araneo, 40, lives at a group home in Bergenfield. He was reported missing by a supervisor. Araneo does not have his ... […]
Schizophrenia: 2018 Pipeline Highlights - ResearchAndMarkets.com
on April 19, 2018 at 8:44 am
DUBLIN--(BUSINESS WIRE)--Apr 19, 2018--The "Schizophrenia Pipeline Highlights - 2018" report has been added to ResearchAndMarkets.com's offering. 'Schizophrenia Pipeline Highlights - 2018' provides the most up-to-date information on key pipeline products ... […]
Podcast: Life With Schizophrenia – One Man’s Experience
on April 19, 2018 at 3:34 am
The onset of mental illness can upend our lives in many ways. In this episode, we speak with a young man living with schizophrenia and hear about the impact it has had on him and his family. He describes his life before his diagnosis and the first symptoms ... […]
Man with schizophrenia reported missing from assisted living facility
on April 18, 2018 at 3:35 pm
MIAMI - A family is desperate to find their loved one who was reported missing. Frantz Paraison, 61, was last seen at his assisted living facility in Miami two weeks ago. "I feel scared because I don't know where my dad is. I just want my dad," Linda ... […]
Depression and schizophrenia common patient complaints at civic hospitals: Study
on April 17, 2018 at 5:41 pm
MUMBAI: An analysis of patients visiting major civic-run hospitals shows common mental disorders, inlcuding depression, anxiety and panic attacks and phobias, draw as many patients as major psychiatric illnesses like schizophrenia or bipolar disorder. […]
I Worry That I May Have Schizophrenia
on April 17, 2018 at 4:33 am
I’ve been observing myself, paying attention to everything around me as much as i can, and i’ve noticed that i have many symptoms similar to the symptoms of schizophrenia. I’ve been experiencing hallucinations and delusions, mainly delusions. […]
Cutting-edge Advances Help Mute Voices in Schizophrenia
on April 12, 2018 at 1:50 pm
FLORENCE, Italy — Schizophrenia patients with auditory verbal hallucinations (AVH) that have not responded to treatment may experience improvement with two cutting-edge techniques, new research shows. A study by Alexandre Dumais, MD, PhD, Institute ... […]
Schizophrenia as Plot Device: Inherently Stigmatizing?
on April 8, 2018 at 11:46 am
In Trespassing (2018) by Brandi Reeds, a woman with a family history of schizophrenia discovers her husband missing under mysterious circumstances. As the story unfolds, she finds it harder and harder to differentiate between an unbelievable reality and ... […]
via Google News and Bing News