Sep 142013
 

CellTransplant_BODY

Rodent research suggests feasibility of restoring neuron function

Research from the School of Medicine at The University of Texas Health Science Center at San Antonio suggests the exciting possibility of using cell transplants to treat schizophrenia.

Cells called “interneurons” inhibit activity within brain regions, but this braking or governing function is impaired in schizophrenia. Consequently, a group of nerve cells called the dopamine system go into overdrive. Different branches of the dopamine system are involved in cognition, movement and emotions.

“Since these cells are not functioning properly, our idea is to replace them,” said study senior author Daniel Lodge, Ph.D., assistant professor of pharmacology in the School of Medicine.

Transplant restored normal function

Dr. Lodge and lead author Stephanie Perez, graduate student in his laboratory, biopsied tissue from rat fetuses, isolated cells from the tissue and injected the cells into a brain center called the hippocampus. This center regulates the dopamine system and plays a role in learning, memory and executive functions such as decision making. Rats treated with the transplanted cells have restored hippocampal and dopamine function.

Stem cells are able to become different types of cells, and in this case interneurons were selected. “We put in a lot of cells and not all survived, but a significant portion did and restored hippocampal and dopamine function back to normal,” Dr. Lodge said.

‘You can essentially fix the problem’

Unlike traditional approaches to treating schizophrenia, such as medications and deep-brain stimulation, transplantation of interneurons potentially can produce a permanent solution. “You can essentially fix the problem,” Dr. Lodge said. “Ultimately, if this is translated to humans, we want to reprogram a patient’s own cells and use them.”

Read more . . .

via University of Texas Health Science Center at San Antonio
 

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  4 Responses to “Cell transplants may be a novel treatment for schizophrenia”

  1. is it available?how much money we have t pay for it?

    • You would have to contact them directly. Follow the link to their page and go from there.

      Good luck.

  2. it is very difficult to wait more..it is 10 years that scientists are working about transplant new cells to cure all illness.but it is not still available.it seems to be easy..it is not too difficult..why it is not still available?. we need it for my sister.please save her life..we will pay how much money you want..is it available for people? can we us it?

  3. it is amazing.but how much we have to wait for it .is very difficult to wait more.please tell us how much money we have to pay and when it will be available for people. we need it..

Your comments and ideas are most welcome

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