A quick sniff of a nasal spray sends microscopic metal particles into the brain, where they target and destroy the damaging proteins of Alzheimer’s disease.
No Alzheimer’s? No problem—the metal particles pass out of the body safely. Such is the promise of technology being developed by neuroscientist William Klein and nanotechnologist Vinayak Dravid of Northwestern University. The pair has invented a nanotech-based early-detection system that might one day deliver targeted treatments.
Klein and Dravid created an antibody—an immune molecule that detects specific chemical structures—that binds to a particle implicated in Alzheimer’s. They linked the antibody to a nanoscale arrangement of iron oxide compounds, similar to rust, which can be seen with magnetic resonance imaging. The brain scan could detect the disease early on, so patients can start treatment sooner than they can today. “Once the chain reaction of negative events starts, it’s like a lit fuse. You want to intervene as soon as possible,” Klein says.
Globs of beta-amyloid protein called plaques are a hallmark of Alzheimer’s. But these days most neuroscientists agree that a tiny particle form of the same protein, called an oligomer, is the primary toxin in the illness. Eventually these smaller structures glom together to form plaques, but by then they have already damaged brain cells. The antibody created at Northwestern binds to the toxic oligomers and could one day deliver therapies to the brain or help clinicians evaluate how a patient is responding to a new medication.
The Latest on: Alzheimer’s Disease
- Personality changes occur early on during development of Alzheimer's disease, research finds on January 23, 2018 at 5:22 pm
A key feature of Alzheimer's disease is memory loss and losing one's ability to think and make decisions (also called "cognitive ability"). Those changes can begin slowly, during a phase called "mild cognitive impairment" (or MCI). A variety of diseases ... […]
- Has a family member received a Dementia, Parkinson’s Disease or Alzheimer’s diagnosis? on January 23, 2018 at 5:10 pm
Or do you suspect one of these diseases may be impacting your loved one’s life? Here are some signs that should point you to consult a physician or assisted living professional: Memory loss - While it’s normal to forget appointments, names, or ... […]
- Alzheimer's study aims to predict who will develop disease on January 23, 2018 at 2:01 pm
CHICAGO, Jan. 22 (Xinhua) -- Researchers at Washington University School of Medicine have engaged in a long-term study of adult children of Alzheimer's patients, aiming to define who is likely to develop the disease and when, and to establish a timeline ... […]
- New Study Shows That Anxiety May Be An Early Indicator Of Alzheimer’s Disease on January 23, 2018 at 10:14 am
Morgan is a writer on the branded content team who loves breakfast food almost as much as she loves dogs. Doctors have long attested that the brain deterioration caused by Alzheimer’s disease can begin up to 20 years before dementia kicks in, which is ... […]
- Tamamis receives NIH grant to study potential therapeutics for Alzheimer’s disease, Parkinson’s disease and type 2 diabetes on January 23, 2018 at 9:16 am
Dr. Phanourios Tamamis, assistant professor in the Artie McFerrin Department of Chemical Engineering at Texas A&M University, has been awarded a grant from the National Institute on Aging of the National Institutes of Health (NIH) for his research on ... […]
- Women seek to increase Alzheimer's awareness on January 23, 2018 at 7:34 am
Then she started making mistakes. Ultimately, one got her fired. Two weeks later, she got a diagnosis: early onset Alzheimer’s disease. Coleman, dressed in purple — the official color of the Alzheimer’s advocacy movement — recounted those awful ... […]
- ProMIS Neurosciences Lead Product Candidate for Alzheimer's Disease Shows Potential for Improved Therapeutic Potency versus O... on January 23, 2018 at 3:30 am
TORONTO and CAMBRIDGE, MA, Jan. 23, 2018 /PRNewswire/ - ProMIS Neurosciences, Inc., a biotechnology company focused on the discovery and development of precision treatments for neurodegenerative diseases, today announced further results of its previously ... […]
- These Non-Drug Methods Could Help People With Alzheimer's Disease, Study Suggests on January 22, 2018 at 12:00 am
For more, visit TIME Health. While there are no drugs that can treat Alzheimer’s disease and reverse the memory and thinking problems it causes, a new study shows that some non-drug strategies may help to improve cognitive skills in some people with the ... […]
- Keck awarded grant for Alzheimer’s research on January 21, 2018 at 6:42 pm
Three researchers from the USC Keck School of Medicine were among a group of medical institutions awarded a total of $70 million over the next five years by the National Institutes of Health to develop new infrastructure targeting Alzheimer’s disease ... […]
- Did Ronald Reagan Have Alzheimer's Disease While in Office? on January 18, 2018 at 12:30 pm
The publication in 2018 of a tell-all book about the Trump White House in which aides are reported to have questioned President Trump’s mental stability has revived longstanding rumors holding that Ronald Reagan suffered from Alzheimer’s Disease during ... […]
via Google News and Bing News