The same compound in a common household clothes detergent shows promise as a treatment to preserve muscle tissue after severe injury.
The research in rats, published online ahead of print in PLOS ONE, found that injections of the compound sodium percarbonate (SPO) can produce enough oxygen to help preserve muscle tissue when blood flow is disrupted.
“Some commercial detergents generate oxygen bubbles to help clean clothes or remove stains,” said Benjamin Harrison, Ph.D., co-author and associate professor of regenerative medicine at Wake
Forest Baptist. “We modified the material so it can be injected into muscle and provide a boost of oxygen to slow down muscle death until surgery can restore blood flow. Potential applications include treating amputations, crush injuries from car accidents or even blast injuries suffered by those in combat zones.”
SPO is a combination of sodium carbonate and hydrogen peroxide molecules. In the presence of water, it decomposes into oxygen and other salts. The current formulation used by the researchers
generates oxygen for about three hours.
“Normally, when blood flow to muscle tissue is reduced due to severe injury, the muscle begins to die,” said Harrison. “Providing extra oxygen to oxygen-deprived muscle following injury is currently a major medical challenge. The few treatments that are available are primarily aimed at increasing the oxygen-carrying capacity of blood and require an intact system of blood vessels to carry that fluid, which we don’t always have in damaged tissue.”
When muscles don’t have enough oxygen, they lose the ability to contract and their delicate metabolic balance (homeostasis) is impaired. The current project measured the effects of injecting oxygen-starved muscles with SPO. The first phase of this study, involving laboratory studies of muscle outside the body, compared SPO-treated muscles with non-treated muscles and found that SPO was effective at preserving both function and homeostasis in oxygen-deprived muscles.
“Our surprising finding was that even after exercising isolated leg muscles in the absence of oxygen, the muscles injected with the SPO compound could generate 20 percent more force than untreated
muscles,” said Harrison. “These studies were conducted using a standard laboratory test to evaluate muscle function outside the body.”
Another part of the study involved rats in which the blood flow to a leg was interrupted and muscle function was studied while still in the body. The scientists measured flexion of the foot in response to nerve stimulation, which causes contraction of the tibialis anterior muscle. Even 30 minutes after the start of exercise (muscle stimulation), oxygen-deprived muscles injected with SPO maintained 30 percent of normal force. In muscles not treated with SPO, there was nearly complete cessation of
contraction under identical conditions.
“This research, which evaluated muscles both outside and within the body, is the first to demonstrate that an oxygen-generating compound helps preserve muscle function and metabolic balance after
oxygen-deprivation,” said Harrison. “It may be a way to get oxygen to muscles when blood flow is severely compromised.”
Harrison said additional work is still needed to determine if SPO will be effective in larger muscles and can be dispersed throughout the muscle, as well as if it can be applied to humans.
If successful, Harrison said the treatment could potentially extend the window of time, known as the “golden hour” in emergency medicine, when treatment has the highest chance of preventing death.
“The major implication of these findings is that oxygen-generating compounds can potentially reduce the magnitude of the permanent functional deficits resulting from traumatic injury to muscle, said George Christ, Ph.D., co-author and professor of regenerative medicine at Wake Forest Baptist. “This effect alone would be extremely valuable to both wounded warriors and civilians.However, it is also conceivable that the technology, because it delivers oxygen independent of blood flow, may also have diverse applications to the salvage, repair and regeneration of soft tissue following trauma.”
The Latest on: Saving Tissue after Severe Injury
Puna man ‘just wanted to live’ after nearly losing leg to lava bomb
on May 24, 2018 at 3:07 am
There they cleaned lava rock out of the wound, placed a flap over the void where he lost a lot of tissue, inserting a titanium rod ... I just can’t believe it’s there.” Despite the severe injury and Civil Defense warnings to evacuate, Clinton has ... […]
Kilauea lava bomb survivor describes agony of his injury
on May 23, 2018 at 12:07 pm
He was rushed to Hilo Medical Center, where he said physicians cleaned out his wound, removed tissue they could not save and, to his surprise ... Witnessing the lava up close, injury notwithstanding, had been unforgettable, he said. […]
Mumbai: 23-year-old who almost lost leg after Fatka gang member's assault forgives him
on May 19, 2018 at 7:00 pm
While she managed to step out in the nick of time, miraculously saving herself ... of her left hand due to severe crush injuries. The great toe also had to be amputated," he says. Also read - Mumbai: Woman falls off train after being hit by 'Fatka gang ... […]
DUI suspect smiles for mug shot hours after crash that left a woman dead
on May 18, 2018 at 7:36 am
doctors rushed to save the life of Sandra ... Welk told police she was distracted after dropping her cellphone before she smashed into the vehicle driven by Clarkson’s 18-year-old daughter, Shiyanne Kroll, who suffered minor injuries, Village News ... […]
6-Year-Old Jumps Into Action to Save Younger Siblings After Horrific Car Crash: It 'Was Amazing'
on May 14, 2018 at 12:29 pm
But the mom says the emotional injuries have been the worst to ... Now, as the family heals after the accident, Sarah is crediting the five-point harness car seats with saving the children’s lives. “The EMT did tell me that probably did save their ... […]
Peak of Health: Orthopedic traumatologists: Treating injuries
on January 9, 2017 at 6:26 pm
and requires immediate care to save a life and/or limb. Orthopedic trauma injuries can range from simple isolated fractures, joint injuries and soft tissue tears to severe life-threatening injuries with multiple broken bones. Most orthopedic traumas affect ... […]
Oxygen-generating compound shows promise for saving tissue after severe injury
on August 26, 2013 at 2:03 pm
The same compound in a common household clothes detergent shows promise as a treatment to preserve muscle tissue after severe injury. Researchers at the Wake Forest Baptist Medical Center's Institute for Regenerative Medicine hope the oxygen-generating ... […]
Oxygen-Generating Compound Shows Promise for Saving Tissue After Severe Injury
on August 23, 2013 at 5:00 am
Newswise — WINSTON-SALEM, N.C. – August 26, 2013 – The same compound in a common household clothes detergent shows promise as a treatment to preserve muscle tissue after severe injury. Researchers at the Wake Forest Baptist Medical Center’s ... […]
via Google News and Bing News