Using human pluripotent stem cells and DNA-cutting protein from meningitis bacteria, researchers from the Morgridge Institute for Research and Northwestern University have created an efficient way to target and repair defective genes.
Writing today (Monday, Aug. 12, 2013) in the Proceedings of the National Academy of Sciences, the team reports that the novel technique is much simpler than previous methods and establishes the groundwork for major advances in regenerative medicine, drug screening and biomedical research.
Zhonggang Hou of the Morgridge Institute’s regenerative biology team and Yan Zhang of Northwestern University served as first authors on the study; James Thomson, director of regenerative biology at the Morgridge Institute, and Erik Sontheimer, professor of molecular biosciences at Northwestern University, served as principal investigators.
“With this system, there is the potential to repair any genetic defect, including those responsible for some forms of breast cancer, Parkinson’s and other diseases,” Hou said. “The fact that it can be applied to human pluripotent stem cells opens the door for meaningful therapeutic applications.”
Zhang said the Northwestern University team focused on Neisseria meningitidis bacteria because it is a good source of the Cas9 protein needed for precisely cleaving damaged sections of DNA.
“We are able to guide this protein with different types of small RNA molecules, allowing us to carefully remove, replace or correct problem genes,” Zhang said. “This represents a step forward from other recent technologies built upon proteins such as zinc finger nucleases and TALENs.”
These previous gene correction methods required engineered proteins to help with the cutting. Hou said scientists can synthesize RNA for the new process in as little as one to three days – compared with the weeks or months needed to engineer suitable proteins.
The Latest on: Regenerative medicine
IU Center to Focus on Regenerative Medicine
on August 15, 2018 at 8:41 am
The Indiana University School of Medicine has announced plans for a new center focused on regenerative medicine. IU will invest more than $20 million over the next five years to establish the Indiana ... […]
BRIEF-China Regenerative Medicine International Says Unit Gets Nod To Set Up Shenzhen Tissue Engineering Laboratory
on August 15, 2018 at 8:23 am
Aug 15 (Reuters) - China Regenerative Medicine International Ltd: * ANNOUNCES APPROVAL FOR ESTABLISHMENT OF SHENZHEN TISSUE ENGINEERING LABORATORY BY A UNIT * CHINA REGENERATIVE MEDICINE INTERNATIONAL ... […]
29 PhD positions in Regenerative Medicine
on August 15, 2018 at 7:55 am
University Medical Center Utrecht and Utrecht University offer 29 PhD positions within the international doctorate programme ‘RESCUE’ of the Regenerative Medicine Centre Utrecht. You will be trained b... […]
Frequency Therapeutics Strengthens Scientific Advisory Board with Addition of Leading Experts in Neurology, Stem Cell and Regenerative Medicine
on August 14, 2018 at 4:01 am
WOBURN, Mass.--(BUSINESS WIRE)--Aug 14, 2018--Frequency Therapeutics, a clinical stage biotechnology company, today announced the addition of two new members to its PCA Regenerative Medicine Scientifi... […]
Hijacking cellular 'mail' for regenerative medicine
on August 13, 2018 at 11:21 am
University of Illinois at Chicago researchers have received approximately $2 million in funding from the National Institutes of Health to develop a better way to regenerate bone or tissues that have b... […]
The Alliance for Regenerative Medicine Releases Q2 2018 Data Report, Highlighting Sector Trends and Metrics
on August 8, 2018 at 8:18 am
WASHINGTON, D.C., Aug. 08, 2018 (GLOBE NEWSWIRE) -- The Alliance for Regenerative Medicine (ARM) today released its most recent quarterly data report, offering an in-depth look at cell therapy, gene t... […]
Ambys Medicines Launches with $140 Million to Pioneer Regenerative Medicine Therapies for Serious Liver Diseases
on August 8, 2018 at 4:43 am
REDWOOD CITY, Calif.--(BUSINESS WIRE)--Aug 8, 2018--Ambys Medicines, a company founded to capitalize on advances in liver biology and regenerative medicines to develop therapies for serious liver dise... […]
Regenerative Medicine Market worth USD 64919.7 Million by 2025 | CAGR of 33.05% – Progressive Markets
on August 6, 2018 at 8:00 pm
Progressive Markets published a report, titled, Regenerative Medicine Market: Size, Trend, Share, Opportunity Analysis & Forecast, 2016-2025, which projects that the market was valued at $6677.7 milli... […]
Samumed raises $438 million for regenerative therapies
on August 6, 2018 at 1:15 pm
Samumed, LLC has raised $438 million, the San Diego regenerative medicine company said Monday. The new financing round brings the total to more than $650 million since Samumed’s founding, valuing the ... […]
Histogenics: A Glimpse Into The Future Of Regenerative Medicine
on August 3, 2018 at 12:19 am
Histogenics is a powerful grower brewing a highly promising regenerative medicine (NeoCart). In harnessing the power of the next-generation tissue engineering, NeoCart can provide rapid pain relief an... […]
via Google News and Bing News