Using human pluripotent stem cells and DNA-cutting protein from meningitis bacteria, researchers from the Morgridge Institute for Research and Northwestern University have created an efficient way to target and repair defective genes.
Writing today (Monday, Aug. 12, 2013) in the Proceedings of the National Academy of Sciences, the team reports that the novel technique is much simpler than previous methods and establishes the groundwork for major advances in regenerative medicine, drug screening and biomedical research.
Zhonggang Hou of the Morgridge Institute’s regenerative biology team and Yan Zhang of Northwestern University served as first authors on the study; James Thomson, director of regenerative biology at the Morgridge Institute, and Erik Sontheimer, professor of molecular biosciences at Northwestern University, served as principal investigators.
“With this system, there is the potential to repair any genetic defect, including those responsible for some forms of breast cancer, Parkinson’s and other diseases,” Hou said. “The fact that it can be applied to human pluripotent stem cells opens the door for meaningful therapeutic applications.”
Zhang said the Northwestern University team focused on Neisseria meningitidis bacteria because it is a good source of the Cas9 protein needed for precisely cleaving damaged sections of DNA.
“We are able to guide this protein with different types of small RNA molecules, allowing us to carefully remove, replace or correct problem genes,” Zhang said. “This represents a step forward from other recent technologies built upon proteins such as zinc finger nucleases and TALENs.”
These previous gene correction methods required engineered proteins to help with the cutting. Hou said scientists can synthesize RNA for the new process in as little as one to three days – compared with the weeks or months needed to engineer suitable proteins.
The Latest on: Regenerative medicine
Caladrius Receives FDA Regenerative Medicine Advanced Therapy Designation for CD34+ Cell Therapy for Treating Refractory Angina
on June 19, 2018 at 6:38 am
June 19, 2018 08:00 ET | Source: Caladrius Biosciences, Inc. BASKING RIDGE, N.J., June 19, 2018 (GLOBE NEWSWIRE) -- Caladrius Biosciences, Inc. (Nasdaq:CLBS) (“Caladrius” or the “Company”), a clinical-stage biopharmaceutical company with multiple ... […]
CollPlant Appoints Professor Shay Soker from Wake Forest Institute for Regenerative Medicine to its Scientific Advisory Board
on June 19, 2018 at 5:09 am
NESS ZIONA, Israel, June 19, 2018 /PRNewswire/ -- CollPlant (CLGN) (CLGN.TA), a regenerative medicine company utilizing its proprietary plant-based rhCollagen (recombinant human collagen) technology for tissue repair products, today announced the ... […]
This month's episode: Orthopedic regenerative medicine
on June 15, 2018 at 8:20 am
The human body has an amazing ability to repair itself, but damage to unhealthy tissues can slow healing down or even prevent it. A new field known as regenerative medicine uses advances in molecular biology to give new hope to patients and new treatment ... […]
Nightstar Therapeutics Receives Regenerative Medicine Advanced Therapy (RMAT) Designation for NSR-REP1 in Choroideremia
on June 14, 2018 at 11:11 am
WALTHAM, Mass. and LONDON, June 14, 2018 (GLOBE NEWSWIRE) -- Nightstar Therapeutics plc (NITE), a clinical-stage gene therapy company developing treatments for rare inherited retinal diseases, today announced that the U.S. Food and Drug Administration (FDA ... […]
Regenerative Medicine Market, 2022
on June 12, 2018 at 11:00 am
The "Global Regenerative Medicine Market Analysis & Forecast to 2022; Stem Cells, Tissue Engineering, BioBanking & CAR-T Industries" report has been added to ResearchAndMarkets.com's offering. This report provides a comprehensive overview of the size of ... […]
Global Regenerative Medicine Market Worth $66 Billion by 2022 With CAGR of 23.3%
on June 12, 2018 at 6:26 am
ReportsnReports.com adds Global Regenerative Medicine Market Analysis & Forecast to 2022; Stem Cells, Tissue Engineering, BioBanking & CAR-T Industries research report. This report provides a comprehensive overview of the size of the regenerative medicine ... […]
Global Regenerative Medicine Market Analysis & Forecast to 2022; Stem Cells, Tissue Engineering, BioBanking & CAR-T Industries
on June 12, 2018 at 6:26 am
Regenerative medicine's main objective is to heal and replace organs/cells that have been damaged by age, trauma or disease. Congenital defects can also be addressed with regenerative medicine. Therefore, it's market encompasses dermal wounds ... […]
Global Regenerative Medicine Market Analysis & Forecast 2018-2022: Market to Grow to Over $66 Billion, at a CAGR of 23.3%
on June 12, 2018 at 3:21 am
13.1 Challenges Relating to Cell therapy and Chimeric Antigen Receptor T Cells in Immunotherapy 13.2 Regulations Pertaining to Immunotherapy, including Adoptive Cell Therapy (CAR-T and TCR) Immunotherapy Regulation in the USA 13.3 Regulations for Cell ... […]
Global Regenerative Medicine Market Expected to Reach $39,325 Million by 2023, Says Allied Market Research
on June 11, 2018 at 7:34 am
Currently, majority of the available treatments for degenerative or life-threatening diseases do not provide a cure or are palliative; however, regenerative medicines have the capability to replace or regenerate the tissues and organs that are injured or ... […]
via Google News and Bing News