The fight against antibiotic-resistant superbugs has taken a step forward thanks to a new discovery by scientists at The University of Nottingham.
A multi-disciplinary research team at the University’s Centre for Biomolecular Sciences has uncovered a new way of inhibiting the toxicity and virulence of the notorious superbug, Pseudomonas aeruginosa.
This bacteria produces an armoury of virulence factors and is resistant to many conventional antibiotics. It is almost impossible to eradicate P. aeruginosa from the lungs of people with cystic fibrosis and is therefore a leading cause of death among sufferers. The bug also causes a wide range of infections particularly among hospital patients.
The new discovery concerns the bacterial cells’ ability to ‘talk’ to each other by producing and sensing small chemical signal molecules. This is called ‘quorum sensing’ (QS) and enables a population of individual bacteria to act socially rather than as individuals. QS allows a population of bacteria to assess their numerical strength and make a decision only when the population is ‘quorate’.
The mechanism through which QS signals work is by activating gene expression upon interaction of a QS signal molecule with a receptor protein. In many disease-causing bacteria, QS controls genes which are essential for infection. These genes code for virulence factors such as toxins which cause damage to host tissues and the immune system. Interfering with the QS signalling process blocks bacterial virulence and renders bacteria unable to cause infection. Consequently QS systems are molecular targets for the development of new anti-infective drugs which do not kill bacteria but instead block their ability to cause disease.
The Latest on: Superbugs
- Four weeks until SMi’s 21st Annual Superbugs & Superdrugs Conference 2019 on February 19, 2019 at 10:20 am
SMi Reports: Senior industry experts will gather in London to discuss the recent advances made in combating antibiotic resistance. As the global threat of antimicrobial resistance continues to grow, t... […]
- Senior Experts from WHO, HPRA, Wellcome Trust, Centauri Therapeutics to present at 21st Annual Superbugs & Superdrugs Conference in 4 weeks’ time on February 18, 2019 at 2:03 am
In just 4 weeks’ time, SMi's 21st Annual Superbugs & Superdrugs Conference will kick off in London, setting out to provide an international audience with key updates on the latest developments in comb... […]
- How scientists can use insects to fight superbugs on February 15, 2019 at 12:34 pm
The microbes living inside insects could help scientists fight antibiotic-resistant bacteria, NPR reports. Scientists have uncovered dozens of microorganisms living in or on insects that produce antim... […]
- New approach could help stop ‘superbugs’ on February 13, 2019 at 8:47 pm
Think of it as decontaminating yourself. Hospitalized patients who harbor certain superbugs can cut their risk of developing full-blown infections if they swab medicated goo in their nose and use ... […]
- Squeaky clean: Hygiene cuts superbugs after hospitalization on February 13, 2019 at 4:53 pm
(AP) A new study shows a way people can cut their risk of developing a dangerous superbug infection after leaving the hospital. Patients who were found to carry bacteria called MRSA on their skin or i... […]
- Vancouver-based innovator Axine offers a solution for wastewater treatment on February 13, 2019 at 12:41 pm
One of the biggest culprits in creating these superbugs, ironically, is pharmaceutical companies—or, more specifically, their wastewater. Like any manufacturing plant, big pharma factories require wat... […]
- Bugs Vs. Superbugs: Insects Offer Promise In Fight Against Antibiotic Resistance on February 13, 2019 at 11:40 am
Nobody likes a cockroach in their house. But before you smash the unwelcome intruder, consider this: that six-legged critter might one day save your life. That's right. Insects—long known to spread di... […]
- Where antibiotics are more common than water, superbugs thrive on February 13, 2019 at 1:30 am
Above one of the doors of the Mirigu health center in the Upper East Region of Ghana, the words "labour ward" are written in black marker. In a cramped room no more than a few meters wide, midwife Fel... […]
- Fighting Infection and Tackling Superbugs: Montefiore Hires New Hospital Epidemiologist on February 12, 2019 at 6:50 am
BRONX, N.Y., Feb. 12, 2019 /PRNewswire/ -- Montefiore Health System has promoted Dr. Theresa Madaline to the position of Hospital Epidemiologist, a role dedicated to safeguarding the hospital and its ... […]
- 'We're holding up a floodgate': B.C. fights off superbugs brought home by medical tourists on February 9, 2019 at 2:00 am
The risks involved in medical tourism aren't just personal. Having surgery abroad could also mean bringing back a drug-resistant superbug and putting people in this country at risk, B.C. officials war... […]
via Google News and Bing News