Researchers from Case Western Reserve University School of Medicine have developed an unprecedented approach to restore nitric oxide (NO) to donated blood, a breakthrough that could dramatically reduce harmful effects from transfusions.
Jonathan Stamler, MD, and colleagues from Case Western Reserve School of Medicine and from Duke University Medical Center describe their findings in the June 24 issue of PNAS: Proceedings of the National Academy of Sciences of the United States of America. Stamler and his colleagues report that restoring blood levels of NO in animals prior to transfusion improved their tissue blood flow, oxygen delivery, and kidney function.
Patients in the U.S. receive approximately 15 million blood transfusions a year. The procedure is often used to replace blood lost through trauma, but also can supplement shortages in a patient’s own ability to produce blood due to cancer and other diseases. Increasingly, medical research publications associate transfusions with harmful consequences including heart attacks, renal failure, and death. A compelling explanation put forward in the literature is that the quantity of NO declines rapidly after donation because it has a short lifespan. Normally, NO dilates blood vessels and allows red blood cells to access tissue and deliver oxygen.
In the blood, NO exists in a bioactive form called S-nitrosohemoglobin (SNO-Hb). The unique process Stamler and team developed to restore SNO-Hb — so-called renitrosylation therapy — could have significant benefits for millions of patients.
“Inasmuch of the world’s supply of banked blood is deficient in SNO-Hb, efforts to restore its levels may hold great therapeutic promise,” said Stamler, director, Institute for Transformative Molecular Medicine and the Robert S. and Sylvia K. Reitman Family Foundation Distinguished Chair in Cardiovascular Innovation, Case Western Reserve School of Medicine and University Hospitals (UH) Case Medical Center, and director, Harrington Discovery Institute, UH Case Medical Center.
“One important aspect of our study is the insight that knowledge of banked blood’s SNO-Hb status may be used to judge the efficacy of a transfusion,” Stamler said.
This information would allow physicians to discriminate between blood donations that may cause harm versus those that will have restorative effects following transfusion.
The research team hypothesized that the loss of NO compromises the ability to dilate blood vessels and thereby deliver oxygen to tissues, which is critical for survival. Red blood cells lacking NO instead would plug small blood vessels and cause heart attacks and kidney failure. In contrast, restoration of NO would ensure oxygen delivery.
The study, funded by the National Heart Lung and Blood Institute (NHLBI), found that mice, rats and sheep transfused with untreated banked blood had decreased oxygen levels in skeletal muscle and other tissues—exactly the opposite of what would have been predicted. By contrast, in animals transfused with renitrosylated (NO repleted) red blood cells, tissue oxygenation improved. In addition, researchers applied the same treatment to anemic animals and found improved blood flow, tissue oxygenation, and kidney function.
Stamler explained that these results demonstrate that restoration of blood NO levels may be useful in treating and preventing a wide variety of conditions, including heart attacks and strokes, and kidney damage following surgery. The findings also may offer new promise for patients with sickle disease, malaria and other blood disorders. In addition, the data suggest that Stamler’s therapeutic is a simple way to reverse the potential toxicity of regular blood transfusions.
The Latest Bing News on:
- Mylan Can't Expedite Novartis Blood Transfusion IP Fighton October 13, 2020 at 10:57 am
A London judge has refused to expedite Novartis AG's lawsuit against Mylan over the rival drugmaker's plans to sell a generic version of its blood transfusion drug, saying its request to hold the ...
- Worldwide Industry for Blood Transfusion Diagnostics to 2027 - Strategic Recommendations for New Entrants - ResearchAndMarkets.comon October 13, 2020 at 7:55 am
The "Blood Transfusion Diagnostics - Global Market Outlook (2019-2027)" report has been added to ResearchAndMarkets.com's offering.
- Blood donation scheduled in Foreston October 13, 2020 at 6:00 am
There will be a blood donation opportunity from 2 to 7 p.m. Wednesday, Oct. 21 at McVitty Memorial VFW Post 1182, 204 W. Lima St., Forest.
- Cerus bags $11M FDA contract to treat whole blood; shares +5%on October 13, 2020 at 5:54 am
Cerus (NASDAQ:CERS) has been awarded a five-year contract valued at $11.1M with the FDA for the development of next-generation compounds to optimize pathogen reduction (PR) treatment of whole blood to ...
- Synthetic Blood Substitutes Market Size Worth USD 15.40 Billion by 2027 | CAGR of 18.5%: Emergen Researchon October 13, 2020 at 5:01 am
The Global Synthetic Blood Substitutes Market is projected to worth USD 15.40 Billion by 2027, according to a new report by Emergen ...
- Donate blood during Breast Cancer Awareness Monthon October 12, 2020 at 10:28 am
During Breast Cancer Awareness Month in October, the American Red Cross urges eligible donors to donate blood or platelets to help patients fighting cancer. Those who give blood or platelets Oct.
- Global Blood Transfusion Diagnostics Market Outlook to 2027 - Impact of COVID-19on October 12, 2020 at 2:40 am
The "Blood Transfusion Diagnostics - Global Market Outlook (2019-2027)" report has been added to ResearchAndMarkets.com's offering. According to the report, the Global blood Transfusion Diagnostics ...
- Wrong transfusion: NGO to move HC after Bathinda cops book one blood bank employeeon October 11, 2020 at 5:24 am
Probe had indicted three employees for negligence The Bathinda police have registered a case against one employee of the blood bank in the wrong blood transfusion incident at Bhai Mani Singh Civil ...
- Three suspended for wrong blood transfusionon October 10, 2020 at 6:37 pm
Acting on the report of an inquiry committee in connection with the wrong blood transfusion incident at a hospital here, the Director, Health and Family Welfare Department, has issued orders ...
- Blood drive held in honor of fallen police officeron October 10, 2020 at 4:23 pm
The Gill Hall Volunteer Fire Company in Jefferson Hills held a blood drive in memory of a fallen officer. The blood drive was in honor of Officer Dale Provins, who died following a head on crash in ...
The Latest Google Headlines on:
The Latest Bing News on:
Restoring blood levels of NO
- Restoring vision by crippling aberrant blood vessels in the eyeon October 5, 2020 at 12:00 pm
In some forms of retinopathy, blood vessels grow out of control in the eye, blocking light and causing irreversible vision loss. An experimental small molecule blocked proteins in the eye that cause ...
- More Research Highlights From EASD 2020on September 25, 2020 at 4:38 pm
People with type 2 diabetes who were able to achieve an HbA1c level under 6.5% and a fasting blood glucose under 126 ... "There were no periods of pilot incapacitation throughout the whole study ...
- Arthritis treatment: Avoid this type of food to ‘reduce inflammation and restore defences'on September 24, 2020 at 3:08 pm
Unfortunately, there's no cure for arthritis ... at high temperatures in your diet could potentially help reduce blood AGE levels. A healthy approach to eating also brings the added benefit ...
- Type 2 Diabetes Remission Can Restore Pancreas Morphologyon September 24, 2020 at 9:18 am
Moreover, the irregular border seen at baseline normalised, the fat content of the pancreas decreased significantly, and insulin secretion rose to the levels ... We no longer consider it to ...
- Type 2 Diabetes Remission can Restore Pancreas Size and Shapeon September 22, 2020 at 6:43 am
Reversing type 2 diabetes has the ability to restore the insulin-producing ... Type 2 diabetes is caused as a result of too high blood sugar level because the pancreas is not producing enough ...
- Study reveals type 2 diabetes remission can restore pancreas size and shapeon September 22, 2020 at 1:08 am
In 2019, research revealed that achieving remission of type 2 diabetes by intensive weight loss can restore the ... A1c (HbA1c) level of less than 6.5% and fasting blood glucose of less than ...
- Frontline Blood Sugar & Nerve Support Review-Is it Safe? Real Customer Exposed!on September 14, 2020 at 10:21 am
What is Frontline Blood ... with no reported side effects. Unlike toxic medications, everything inside Frontline Blood Sugar & Nerve Support is natural. You might experience some nights where you ...
- Alteplase Versus Urokinase in Restoring Blood Flow in Hemodialysis-Catheter Thrombosison September 9, 2020 at 4:59 pm
Information collected included patient demographics, etiology of end-stage renal disease, age of catheter at time of thrombosis, pretreatment and posttreatment hemodialysis blood-flow rates ...
- Blood Lead Levelson October 22, 2017 at 8:04 am
This is a test that measures the amount of lead in the blood. Blood is drawn ... While lead serves no function in our bodies, it is usually present to some degree since it is so common in our ...