Could mean good news in the battle against superbugs
Antibiotic-resistant bacteria found in one of the deepest, most isolated caves in the world could mean good news in the battle against superbugs. Researchers from McMaster and the University of Akron have discovered a remarkable prevalence of such bacteria in New Mexico’s Lechuguilla Cave, a place isolated from human contact until very recently
The discovery that bacteria have developed defenses against antibiotics could indicate the presence of previously unknown, naturally occurring antibiotics that doctors could use to treat infections.
McMaster’s Gerry Wright, scientific director of the Michael G. DeGroote Institute for Infectious Disease Research, and Hazel Barton, associate professor of biology at the University of Akron, collected strains of bacteria from the cave’s deepest recesses.
None of the bacteria are capable of causing human disease, nor have they ever been exposed to human sources of antibiotics but they pair found that almost all were resistant to at least one antibiotic. Some were resistant to as many as 14 different antibiotics.
In all, resistance was found to virtually every antibiotic that doctors currently use to treat patients.
“Our study shows that antibiotic resistance is hard-wired into bacteria. It could be billions of years old, but we have only been trying to understand it for the last 70 years,” said Wright. “This has important clinical implications. It suggests that there are far more antibiotics in the environment that could be found and used to treat currently untreatable infections.”
The researchers also identified resistance in bacteria related to the bacterium that causes anthrax. This resistance has yet to emerge in the clinic.
“We can say to doctors, ‘While this isn’t a problem right now, it could be in the future, so you need be aware of this pre-existing resistance and be prepared if it emerges in the clinic, or you are going to have a problem,’” said Barton.
Resistance to antibiotics among bacteria is a growing concern for human health. With the emergence of bacteria such as multi-drug resistant Staphylococcus and the global spread of resistance to all clinically used drugs, where and how these organisms acquire resistance are becoming important questions, said Wright.
via Science Daily ᔥ
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