Gladstone Institutes

The Gladstone Institutes is an independent and nonprofit biomedical research organization whose focus is to better understand, prevent, treat and cure cardiovascular, viral and neurological conditions such as heart failure, HIV/AIDS and Alzheimer’s disease.

A potential therapy for heart valve disease

Mass rapid testing moves closer with a new CRISPR-based test for COVID-19 using a smartphone

CRISPR gene editing gets an on switch for better control

CRISPR-Cas9 is a revolutionary tool in part because of its versatility: created by bacteria to chew up viruses, it works equally well in human cells to do all sorts of genetic tricks, including cutting and pasting DNA, making pinpoint mutations and activating or inactivating a gene. UC Berkeley researchers have now made it even more

CRISPR gene editing gets an on switch for better control

A promising new way to fight tuberculosis?

Scientists in the San Francisco Bay Area identify nearly 200 potential drug targets Tuberculosis is one of the top 10 causes of death worldwide. Nearly 2 million people die every year from this infectious disease, and an estimated 2 billion people are chronically infected. The only vaccine, developed almost 100 years ago, offers limited protection

A promising new way to fight tuberculosis?

Transplanting a special type of neuron into the brain restores cognitive functions in Alzheimer’s models

Like a great orchestra, your brain relies on the perfect coordination of many elements to function properly. And if one of those elements is out of sync, it affects the entire ensemble. In Alzheimer’s disease, for instance, damage to specific neurons can alter brainwave rhythms and cause a loss of cognitive functions. One type of

Transplanting a special type of neuron into the brain restores cognitive functions in Alzheimer’s models

Drug discovery made cheaper, quicker and more reliable

Li Gan, PhD, wants to find treatments to help patients with Alzheimer’s disease. Like most researchers, she’s hit a few major roadblocks. When researchers like Gan find potential new drugs, it’s useful to test them on human cells to increase the chances that they will benefit patients. Historically, these tests have been conducted in cancer cells,

Drug discovery made cheaper, quicker and more reliable

A key cellular protein could lead to treatments for neurodegenerative diseases

A new way to regulate protein levels and functions could be the answer to treating devastating neurological conditions New details learned about a key cellular protein could lead to treatments for neurodegenerative diseases, such as Parkinson’s, Huntington’s, Alzheimer’s, and amyotrophic lateral sclerosis (ALS). At their root, these disorders are triggered by misbehaving proteins in the

A key cellular protein could lead to treatments for neurodegenerative diseases

Direct cardiac reprogramming to benefit from heart cells that are better, faster, stronger

Two chemicals improved the speed, quantity, and quality of direct cardiac reprogramming, bringing the technology one step closer to regenerating damaged hearts Scientists at the Gladstone Institutes identified two chemicals that improve their ability to transform scar tissue in a heart into healthy, beating heart muscle. The new discovery advances efforts to find new and

Direct cardiac reprogramming to benefit from heart cells that are better, faster, stronger

Scientists Turn Skin Cells into Heart Cells and Brain Cells Using Drugs

In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals. All previous work on cellular reprogramming required adding external genes to the cells, making this accomplishment an unprecedented feat. The research lays the groundwork for one day being able to regenerate lost

Scientists Turn Skin Cells into Heart Cells and Brain Cells Using Drugs

Combining the two most powerful biological tools of the 21st century to Control Gene Expression in Stem Cells – CRISPRi

Combining the two most powerful biological tools of the 21st century, scientists at the Gladstone Institutes have modified how the genome of induced pluripotent stem cells (iPSCs) is read for the first time using a variation of the CRISPR-Cas9 system. The development offers a major technological advance in creating cell models of genetic diseases. In

Combining the two most powerful biological tools of the 21st century to Control Gene Expression in Stem Cells – CRISPRi

Gladstone scientists discover potential new treatment for multiple sclerosis

Finding could have implications for other autoimmune disorders, such as type I diabetes Scientists from the Gladstone Institutes have discovered a way to prevent the development of multiple sclerosis (MS) in mice. Using a drug that blocks the production of a certain type of immune cell linked to inflammation and autoimmunity, the researchers successfully protected

Gladstone scientists discover potential new treatment for multiple sclerosis

Transplantation of healthy new brain cells reverses learning and memory loss in Alzheimer’s disease model

A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer’s disease, improving cognition to normal levels in aged mice. In the study, which was conducted in collaboration with researchers at UC San Francisco and published today

Transplantation of healthy new brain cells reverses learning and memory loss in Alzheimer’s disease model

Take a pill and boost your IQ?

It did boost cognitive faculties regardless of a person’s age by the equivalent of about six IQ points PEOPLE are living longer, which is good. But old age often brings a decline in mental faculties and many researchers are looking for ways to slow or halt such decline. One group doing so is led by

Take a pill and boost your IQ?

Scientists Transform Skin Cells into Functioning Liver Cells

They have discovered a way to transform skin cells into mature, fully functioning liver cells that flourish on their own, even after being transplanted into laboratory animals modified to mimic liver failure The power of regenerative medicine now allows scientists to transform skin cells into cells that closely resemble heart cells, pancreas cells and even neurons. However,

Scientists Transform Skin Cells into Functioning Liver Cells

Building the Tools that Fight Type 1 Diabetes

Gladstone scientists reprogram skin cells into insulin-producing pancreas cells A cure for type 1 diabetes has long eluded even the top experts. Not because they do not know what must be done—but because the tools did not exist to do it. But now scientists in the laboratory of Gladstone Institutes’ Investigator Sheng Ding, MD, PhD,

Building the Tools that Fight Type 1 Diabetes

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Gladstone Institutes Research

Cytokinetics Hosts Muscle Biology-Focused Research Symposium: Contemporary Landscapes in Muscle Biology
CLIMB is a one-day research symposium bringing together scientists ... Ph.D., L.K. Whittier Director, Gladstone Institute of Data Science and Biotechnology; Professor, Department of Epidemiology and ...
Study suggests two copies of APOE4 gene behind up to 20% of Alzheimer's cases
A team of neurologists affiliated with multiple institutions in Spain and the U.S. has found evidence that suggests up to 20% of all cases of Alzheimer's disease (AD) may be attributable to double ...
Gladstone's Deepak Srivastava Honored as Most Admired CEO by San Francisco Business Times
The San Francisco Business Times has named Gladstone Institutes President Deepak Srivastava, MD, as one of the Most Admired CEOs among Bay Area businesses and nonprofits. In an article now appearing ...
Scientists link oocyte-specific histone H1FOO to better iPS cell generation
A joint research team led by Dr. Akira Kunitomi, a former postdoctoral fellow at CiRA (currently a researcher at the Gladstone Institute of Cardiovascular Disease), and ID Pharma Co., Ltd., has ...
Gladstone's Deepak Srivastava is using collaboration to propel medical research
Through the hardest of times Gladstone Institutes' president is focused on empowering medical research. Here's why Dr. Deepak Srivastava is one of our Most Admired CEOs.

The Latest Bing News on:

Gladstone Institutes Discovery

Lily Gladstone on her new ‘Under the Bridge’ series, stratospheric year
Chatting on Zoom this month in an interview to promote her new Hulu series “Under the Bridge,” Gladstone said that the past year has been astonishing – during awards season, “every day was packed with ...
Gladstone's Deepak Srivastava Honored as Most Admired CEO by San Francisco Business Times
The San Francisco Business Times has named Gladstone Institutes President Deepak Srivastava, MD, as one of the Most Admired CEOs among Bay Area businesses and nonprofits. In an article now appearing ...
Gladstone's Deepak Srivastava Honored as Most Admired CEO by San Francisco Business Times
The company, focused on regenerative medicine and drug discovery for heart failure ... its Most Admired CEOs gala on May 16. About Gladstone Institutes Gladstone Institutes is an independent ...
Gladstone's Deepak Srivastava is using collaboration to propel medical research
Through the hardest of times Gladstone Institutes' president is focused on empowering medical research. Here's why Dr. Deepak Srivastava is one of our Most Admired CEOs.
Therini Bio Announces Positive Preclinical Data Supporting the Development of THN391 in Neurodegenerative Ocular Diseases
THN391 demonstrated effectiveness in protecting against vascular and neuronal degeneration - - Therini Bio plans to initiate a Phase 1/2a trial evaluating THN391 in DME in 2H24 - - The data was ...